Laboratory of Veterinary Immunology

Laboratory of Veterinary Immunology

Immunology is the study of the body’s defense against infection. We are continually exposed to microorganisms, many of which cause disease, and yet become ill only rarely. How does the body defend itself? When infection does occur, how does the body eliminate the invader and cure itself? And why do we develop long-lasting immunity to many infectious diseases encountered once and overcome? These are the questions addressed by immunology, which we study to understand our body’s defenses against infection at the cellular and molecular levels (Janeway’s Immunobiology).

Our group investigates how cells or organisms defend external stressors and adapt to the stress conditions. In particular, 1) we aim to understand how immune cells maintain homeostasis in response to stress in the gut. We are interested in the role of immune cells when gut homeostasis is perturbed, such as dysbiosis or food allergy. Also, 2) we are interested in the molecular mechanisms how cells cope with extreme environmental conditions. To this end, we have been using a non-model unicellular organism, Amoeba proteus.


Lim, Jaechul (|+82-2-880-1232)

Research Interests

  • The homeostatic role of immune cells against stress in the gut
  • Natural IgE antibodies and allergy
  • Dormancy: stress responses to extreme conditions

Recent publication (2020-2022)

  • Lim J*, Lin EV*, Hong JY*†, Vaidyanathan B, Erickson SA, Annicelli C, Medzhitov R†. “Induction of natural IgE by glucocorticoids”, J Exp Med, 219(10):e20220903 (2022).
  • Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JW, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. “Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication”, Mol Cell, 82(9):1631-1642.e6 (2022).
  • Jeong J†, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. “MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells”, Cell Rep, 37(13):110160 (2021).
  • Shin JH†, Jeong J, Maher SE, Lee H, Lim J, Bothwell ALM†. “Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis”, Proc Natl Acad Sci U S A, 118(48):e2110241118 (2021).
  • Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis B, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, Regev A, Medzhitov R. “γδ T cells regulate the intestinal response to nutrient sensing”, Science, 371(6535):eaba8310 (2021).
  • Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Amezcua Vesely MC, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM, Bothwell ALM. “Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1”, iScience, 24(5):102411 (2021).
  • Hong JY, Lim J, Carvalho F, Cho JY, Vaidyanathan B, Yu S, Annicelli C, Ip WKE, Medzhitov R. “Long-term programming of CD8 T cell immunity by perinatal exposure to glucocorticoid”, Cell, 180(5):847-861.e15 (2020).
  • Ye J, Bian X, Lim J, Medzhitov R. “Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids”, Proc Natl Acad Sci U S A, 117(29):17381-17388 (2020).
  • Kim D*, Lee Y-S*, Jung SJ*, Yeo J*, Seo J, Lee YY, Lim J, Chang H, Song J, Yang J, Kim JS, Jung G, Ahn K, Kim VN. “Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing”, Nat Struct Mol Biol, 27(6):581-588 (2020).
  • Hwang SS*, Lim J*, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee KR, Li HB, Flavell RA. “mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence”, Science, 367(6483):1255-1260 (2020).


* Co-first author
† Co-corresponding author

Course Offered

College LevelGraduated Level
– Veterinary Immunology & Laboratory
– Veterinary Clinical Immunology
– Systems Immunology
– Recent Methodologies in Immunology